The Structure of Eosinophil Leukocyte Granules in Rodents and in Man
نویسندگان
چکیده
The structure of the specific granules of eosinophil leukocytes has been studied by electron microscopy in sections of tissues, buffy coats, and sediments of peritoneal washings of rats, mice, guinea pigs, and men. The core of eosinophil granules is a crystal which has a cubic lattice with a repeat of approximately 30 A in rodents and approximately 40 A in man. The chemical composition of the core is discussed in connection with recent cell fractionation studies, and the hypothesis that the core is a crystal of peroxidase is considered.
منابع مشابه
Peripheral Eosinophilia and History of Allergy in Patients with Coronary Artery Disease
Background: Coronary artery diseases (CAD) is the most common cause of death in the developing counteries. Atherosclerosis is the leading cause of CAD. A number of studies have shown that total leukocyte count is a risk factor for CAD but there is little information on the role of eosinophilia and allergy. The aim of this study was to determine the relationship between eosinophilia and histor...
متن کاملChronic eosinophilic leukemia with FIP1L1-PDGFRA.
A 37-year-old man with no significant past family or personal medical history was admitted to the hospital for persistent eosinophilia detected during a routine check-up. He denied recent travel and was not a smoker, alcoholic, or drug addict. He did not have any history of allergic disease and was not exposed to any toxins or pesticides. Physical examination was normal. His complete blood exam...
متن کاملMechanisms of eosinophil secretion: large vesiculotubular carriers mediate transport and release of granule-derived cytokines and other proteins.
Eosinophils generate and store a battery of proteins, including classical cationic proteins, cytokines, chemokines, and growth factors. Rapid secretion of these active mediators by eosinophils is central to a range of inflammatory and immunoregulatory responses. Eosinophil products are packaged within a dominant population of cytoplasmic specific granules and generally secreted by piecemeal deg...
متن کاملSelective histochemical procedure for eosinophil leukocytes.
I N THE COURSE of cunrrent investigations on leukocyte granules, the questioni arose as to w’hether the group responsible for the stable sudanophilia might be a primary amine. It is well known that primary amines are differentially destroyed by nitrous acid,’3 thus: RNH2 + HNO2-ROH + H2O + N2. In testing this hypothesis we used both Vans Slyke’s reagent* arid molar solutionis of sodium nitrite ...
متن کاملEosinophil granules function extracellularly as receptor-mediated secretory organelles.
Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of leukocytes, including eosinophils, cells notably associated with asthma, allergic inflammation, and helminthic infections. Cytokines and chemokines typically elicit extracellular secretion of granule proteins by engaging receptors expressed externa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Cell Biology
دوره 31 شماره
صفحات -
تاریخ انتشار 1966